Division of Cardiothoracic Anesthesia - Department of Anesthesiology
Andrew Shaw, BSc

Division of Cardiothoracic Anesthesia

 

Andrew Shaw, BSc, MBBS, FRCA, FCCM

Andrew Shaw, BScDr. Andrew Shaw received his medical degree from Saint Bartholomew’s Hospital Medical College in London. He completed his basic training in anesthesia at the Imperial School of Anaesthesia in London, and completed his fellowship in Cardiovascular Anesthesia and Critical Care Medicine at the Royal Brompton and Harefield Hospitals in London in 1999. Dr. Shaw spent the earlier part of his career at the MD Anderson Cancer Center in Houston, Texas. In 2005 he came to Duke, where he currently serves as Associate Professor of Anesthesiology.

Dr. Shaw’s current research interests lie in perioperative genetics, particularly the role of genetic variation in the response to cardiothoracic surgery. Further developing his previous work in the risk of pain and morbidity after lung resection, he is using whole genome association study methodology to unravel the genetic determinants of persistent post-thoracotomy pain. He is most noted for his 2008 paper in the New England Journal of Medicine reporting an association between adverse cardiac surgical outcomes and aprotinin. His other work includes the International Perioperative Genetics and Safety Outcome Study (iPEGASUS), a perioperative genetics collaboration in patients undergoing cardiothoracic surgery from around the world. He has also published extensively in the field of cardiac surgery associated acute kidney injury. In this area he serves as SCA representative to the Acute Kidney Injury Network and he is the site principal investigator for the Southern Acute Kidney Injury Network, funded by the NIH.

Dr. Shaw is a Fellow of the Royal College of Anaesthetists (UK) and an elected Fellow of the American College of Critical Care Medicine. In 2006, he was the co-recipient of the ANZCA Harry Daly Research Award (for the iPEGASUS study) and he also received a presidential citation from the Society of Critical Care Medicine in 2007. He serves on the program committee for the Society of Critical Care Medicine and was elected to the Association of University Anesthesiologists in 2008. He has over 100 scientific publications, including 47 original peer reviewed papers.

Grants

  1. Biomarkers in Acute Renal Failure
    PI: Arthur (MUSC) NIDDK R01-DK80234-01
    Grant amount: $204,255
    Grant period: 2008-2013
    Role: Co-investigator
  2. Agennix Inc.: “Safety and Efficacy of Talactoferrin Alfa in Patients with Severe Sepsis.”  Site Principal Investigator. Grant Period: 2008-2009.
  3. Australian and New Zealand College of Anaesthetists Research Award (2006-2008): “iPEGASUS – International Perioperative Genomics and Safety Outcomes Study.” Co-investigator. Grant Period: 2007-2009.
  4. PDL Biopharma Inc.: “Nicardipine neuroprotection in Aortic Surgery Trial.” Principal Investigator. Grant Period: 2007-2009.
  5. Duke Anesthesia Dept Pilot Grant: “KITS – Ketamine in Thoracic Surgery.” Mentor to Dr D’Alonzo. Grant Period: 2007-2008.
  6. Thoracic Surgery Foundation for Research and Education: “Inflammatory Gene Polymorphisms and Atrial Fibrillation After Lung Surgery.” Co-Investigator. Grant Period: 2005-2007.
  7. NIDDK/VA system (CSP 530 Contract): “Intensive Vs Conventional Renal Support in Acute Renal Failure.” Site Principal Investigator. Grant Period: 2003-2006.
  8. Fleming/Davenport Foundation Grant: “Inflammatory Gene Polymorphisms and Postoperative Complications.” Mentor. Grant Period: 2005-2006.
  9. MD Anderson Lung MRP Grant MDACC: “Inflammatory gene polymorphisms and postoperative complications.” Project 1 Leader. Grant Period: 2002-2005.
  10. Eli Lilly and Co.: “A Randomized, Double-Blind, Placebo-Controlled Trial of Prophylactic Heparin in Patients with Severe Sepsis and Higher Disease Severity Who Are Undergoing Treatment with Drotrecogin Alfa (Activated).” Site Principal Investigator. Grant Period: 2003-2004.
  11. Abbott Laboratories Inc.: “Dexmedetomidine and Non Invasive Ventilation: a Case-Control Study.” Principal Investigator. Grant Period: 2002-2004.
  12. Eli Lilly and Co.: “A Safety Evaluation of Xigris (Drotrecogin alfa activated) in Hematopoietic Stem Cell Transplant Patients with Severe Sepsis.” National Principal Investigator. Grant Period: 2002-2004.
  13. Eli Lilly and Co.: “Efficacy and Safety of Drotrecogin Alfa (Activated) in Adult Patients with Early Stage Severe Sepsis.” Site Principal Investigator. Grant Period: 2002-2004.
  14. Abbott Laboratories Inc.: “Fenoldopam mesylate in acute tubular necrosis: a prospective RCT.” National Principal Investigator. Grant Period: 2000-2003.
  15. MDACC Institutional Research Grant: “Studies of Tissue Oxygenation in Ischemic and Hemorrhagic Shock.” Principal Investigator. Grant Period: 1999-2000.

Peer-Reviewed Manuscripts

  1. Conlon NP, Shaw AD, Grichnik KP. (2008) Postthoracotomy paravertebral analgesia: will it replace epidural analgesia? Anesthesiol Clin. Jun; 26(2) 369-80.
  2. Swaminathan M, Shaw AD, Greenfield RA, Grichnik KP. (2008) Fatal Thrombosis After Factor VII Administration During Extracorporeal Membrane Oxygenation. J Cardiothorac Vasc Anesth. Apr;22(2):259-60.
  3. Bellomo R, Auriemma S, Fabbri A, D’Onofrio A, Katz N, McCullough P, Ricci Z, Shaw A (2008). The pathophysiology of cardiac surgery-associated acute kidney injury (CSA-AKI). Int J Artif Organs 31(2); 166-179.
  4. Mehta RL, Cantarovich F, Shaw A, Hoste E, Murray P (2008). Pharmacologic approaches for volume excess in acute kidney injury (AKI). Int J Artif Organs 31(2); 127-144.
  5. Shaw AD, Swaminathan M, Stafford Smith M (2008). Acute kidney injury after cardiac surgery – putting together the pieces of the puzzle. Nephron (In press).
  6. Shaw AD, Stafford-Smith M, White WD, Phillips-Bute B, Swaminathan M, Milano C, Welsby IJ, Aronson S, Mathew JP, Peterson ED, Newman MF (2008). The Effect of Aprotinin on Outcome after Coronary Artery Bypass Grafting. N Engl J Med 358(8):14-23.
  7. Stafford-Smith M, Patel UD, Phillips-Bute B, Shaw AD, Swaminathan M (2008) Acute kidney injury and chronic kidney disease after cardiac surgery. Advances in Chronic Kidney Disease (In press).
  8. Shaw AD, Keefe FJ (2008). Genetic and environmental determinants of postthoracotomy pain syndrome. Curr Opin Anesthesiol 21(1):8-11.
  9. Nates JL, Aravindan N, Hirsch-Ginsberg C, Sizer KC, Kee S, Nguyen AT, Chen K, Shaw ADS, Price KJ (2007). Critically ill cancer patients are not consistently hypercoagulable after craniotomy. Neurocrit Care Oct 7(3):211-6.
  10. Swaminathan M, Shaw ADS, Phillips-Bute B, McGugan-Clark P, Archer L, Talbert S, Milano C, Patel U, Stafford-Smith M. (2007) Trends in acute renal failure associated with CABG surgery in the United States. Crit Care Med 35(10): 2286-91.
  11. Aravindan, N, Aravindan, S, Riedel, BJ, Weng, HR, Shaw, AD. (2007) Furosemide prevents apoptosis and associated gene expression in a rat model of surgical ischemic acute renal failure. Ren Fail 2007; 29(4): 399-407.
  12. Shaw ADS (2007). Literature review. J Thorac Cardiovasc Anes 21(3):468-470.
  13. Gal J, Grattan A, Kertai MD, Smith A, Shaw AD, Royston D, Riedel BJ. (2007) Coronary revascularization in transition from on-pump to off-pump: the effect of the off-pump coronary artery bypass on medium-term outcome. J Cardiovasc Surg 48(1):67-72.
  14. Aravindan N, Aravindan S, Shanmugasundaram K, Shaw AD. (2007) Periods of systemic partial hypoxia induce apoptosis and inflammation in rat skeletal muscle. Mol Cell Biochem Aug (302) 1-2:51-8.
  15. Shaw ADS (2007) Exploring the Perioptome: the Role of Genomics in Thoracic Surgery and Anaesthesia. Curr Opin Anaesthesiol 20(1); 32-6.
  16. Sarkiss MG, Yusuf SW, Warneke CL, Botz G, Lakkis N, Hirch-Ginsburg C, Champion JC,Swafford J, Shaw ADS, Lenihan DJ, Durand JB. (2007) Impact of aspirin therapy in cancer patients with thrombocytopenia and acute coronary syndromes. Cancer 109(3); 621-7.
  17. Riedel BJ, Grattan A, Martin BC, Gal J, Shaw ADS, Royston D. (2006) Long-term outcome of patients with perioperative myocardial infarction as diagnosed by Troponin I after routine surgical coronary artery revascularization. J Cardiothorac Vasc Anes 20(6); 781-7.
  18. Shaw ADS (2006) Genetics of postoperative complications following thoracic surgery. Semin Cardiothorac Vasc Anesth 10(4): 327-345.
  19. Hindler K, Shaw ADS, Samuels J, Fulton S, Collard CD, Riedel BJ. (2006) Improved Postoperative Outcomes Associated with Preoperative Statin Therapy. Anesthesiology 105(6):1260-1272.
  20. Aravindan N, Samuels J, Riedel B and Shaw ADS. (2006) Fenoldopam improves corticomedullary oxygen delivery and attenuates angiogenesis gene expression in acute ischemic renal injury. Kid Blood Press Res 2006 29(3):165-174.
  21. Aravindan N, Cata J, Hoffman L, Dougherty P, Riedel B, Price K and Shaw ADS. (2006) Effect of isoflurane, pentobarbital and urethane on apoptosis and apoptotic signal transduction in rat kidney Acta Anaesth Scand 50(10):1229-37.
  22. Aravindan N, Cata JP, Dougherty PM, Shaw ADS. (2006) Effect of fenoldopam on ischemia/reperfusion induced apoptosis. Renal Failure 28 (4): 337-44.
  23. Riedel B, Lim J, Brauer K, Shaw ADS, Reardon M, Rice D. (2006) Diagnosis And Management Of Persistent Pulmonary Thromboembolism. J Cardiothorac Vasc Anes 2006 Aug;20(4):616-9.
  24. Aravindan N and Shaw ADS. (2006) Effect of Furosemide Infusion on Renal Hemodynamics and Angiogenesis Gene Expression in Acute Renal Ischemia / Reperfusion Injury. Renal Failure 2006;28(1):25-35.
  25. Pastores SM, Shaw ADS, Williams MD, Mongan E, Alicea M, Halpern NA. A safety evaluation of drotrecogin alfa (activated) in hematopoietic stem cell transplant patients with severe sepsis: lessons in clinical research. Bone Marrow Transplant. 2005 Oct;36(8):721-4.
  26. Weng HR, Aravindan N, Cata JP, Chen JH, Shaw ADS, Dougherty PM. Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia. Neurosci Lett 2005 Sep 23;386(1):18-22.
  27. Tumlin JA, Finkel KW, Murray PT, Samuels J, Cotsonis G, Shaw ADS. Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial. Am J Kidney Dis 2005 Jul;46(1):26-34.
  28. Martin CB, Shaw ADS, Gal J, Aravindan N, Murphy F, Royston D, Riedel BJ. The comparison and validity of troponin I assay systems in diagnosing myocardial ischemic injury after surgical coronary revascularization. J Cardiothorac Vasc Anesth 2005 Jun;19(3):288-93.
  29. Shaw ADS, Vaporciyan AA, Wu X, King TM, Spitz M, Putnam JB, Dickey BF (2005) Inflammatory gene polymorphisms influence risk of postoperative morbidity after lung resection. Ann Thorac Surg 2005;79:1704-10.
  30. Aravindan N, Williams MT, Riedel BJCJ and Shaw ADS (2005). Transcriptional responses of rat skeletal muscle following hypoxia-reoxygenation and near ischaemia-reperfusion. Acta Physiol Scand 183 (4): 367-377.
  31. Samuels J, Finkel K, Gubert M, Johnson T and Shaw ADS (2005) Effect of fenoldopam mesylate in critically ill patients at risk for acute renal failure is dose dependent. Renal Failure 2005; 27(1):101-5.
  32. Villars P, S Hamlin, J Kanusky and ADS Shaw (2004) The Role of Diastole in Left Ventricular Function Part II: Diagnostic and Therapeutic Dimensions. Am J Crit Care 13 (5): 394-405.
  33. Hamlin S, P Villars, ADS Shaw and J Kanusky (2004) The Role of Diastole in Left Ventricular Function Part I: Biochemical and Biomechanical Events. Am J Crit Care 13 (6): 1-16.
  34. ADS Shaw, N Aravindan, Z Li and BJCJ Riedel. (2003) Temporal variation in tissue oxygen tension and perfusion response to hypoxia and ischaemia: the importance of local control of the microcirculation. Int J Emer Crit Care Med 7(1).
  35. Mitchell JB, ADS Shaw, S Donald, JG Farrimond. (2002) Differential lung ventilation following single lung transplantation for emphysema. J Cardiothorac Vasc Anes 16(4): 459-62.
  36. Shaw ADS, Z Li, Z Thomas and CW Stevens (2002) Assessment of tissue oxygen tension: comparison of dynamic fluorescence quenching and polarographic electrode technique. Crit Care 6(1):76-80.
  37. Wallace SK, CG Martin, ADS Shaw, KJ Price (2001) The influence of an advance directive on the initiation of life support technology in criticallly ill cancer patients. Crit Care Med 29 (12): 2294-8.
  38. Shaw ADS and MJ Boscoe. (1999)  Anaesthetic assessment and management of cardiac patients for non-cardiac surgery. Part II: Management. Int J Clin  Pract 53(5): 353-8.
  39. Shaw ADS and MJ Boscoe. (1999)  Anaesthetic assessment and management of cardiac patients for non-cardiac surgery. Part I: Assessment.   Int J Clin Pract 53(4):281-6.
  40. Shaw ADS, SK Chamberlain, SM Sapsed-Byrne and GG Lockwood. (1998)  Nitrous oxide and carbon dioxide have no effect on the blood-gas solubilities of sevoflurane and isoflurane.  Anesth Analg 87(6):1412-5.
  41. Shaw ADS and JB Mitchell. (1998) Anaesthesia for video-assisted thorascopic patent ductus arteriosus ligation.  Anaesthesia 53(9):914-7.
  42. Shaw ADS, J.Anderson, A. Hayward and N. Parkhouse. (1995)  The early management of large burns. Br J Hosp Med 53(6):247-50.
  43. Shaw ADS, J. Anderson, A. Hayward and N. Parkhouse. (1994) Pathophysiological basis of burn management. Br J Hosp Med 52(11):583-7.
  44. Gaer JA, ADS Shaw, R Wild, RI Swift, CM Munsch, PL Smith and KM Taylor. (1994)  Effect of cardiopulmonary bypass on gastrointestinal perfusion and function.  Ann Thorac Surg 57(2) 371-5.

Books

  1. Shaw ADS, BJCJ Riedel, A Burton, A Fields, TW Feeley (eds) (2005) Acute Care of the Cancer Patient. Taylor and Francis, New York, NY.

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