Division of Cardiothoracic Anesthesia - Department of Anesthesiology
Mihai V. Podgoreanu, MD

Division of Cardiothoracic Anesthesia

 

Mihai V. Podgoreanu, MD, FASE

Mihai V. Podgoreanu, MDDr. Mihai Podgoreanu received his medical degree from Carol Davila University of Medicine and Pharmacy in Bucharest, Romania before attending Yale University for a residency in Anesthesiology. Dr. Podgoreanu came to Duke in 2000 and completed two subspecialty fellowships in Cardiothoracic Anesthesia and Critical Care Medicine, as well as a postdoctoral fellowship in Molecular Genetics. Currently he serves as Assistant Professor of Anesthesiology, Director of the Systems Modeling of Perioperative Cardiovascular Injury Laboratory, and head of the multidisciplinary Duke Perioperative Genomics Program.

Under Dr Podgoreanu’s leadership several original articles identifying genetic variants associated with perioperative myocardial infarction, stroke, cognitive decline, acute kidney injury, bleeding, and sepsis have been published, as well as review articles and book chapters introducing the concept of perioperative genomics to perioperative physicians and the broader cardiovascular community, including the first genomic chapter in a premiere anesthesiology textbook. He is noted for his patented work “Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke”. As a physician-scientist, Dr Podgoreanu has demonstrated a successful track record of sustained grant funding from the American Heart Association and the National Institutes of Health, and is currently Principal Investigator on two R01 grants from the National Heart Lung and Blood Institute, as well as the recipient of the Duke Clinical Innovations Award. His laboratory uses systems and comparative biology approaches integrating molecular profiling in cellular, animal models of cardiac surgery (rat and pig), and clinical specimens from patients undergoing cardiac surgery to understand the mechanisms underlying the acute myocardial responses to surgical injury and identify novel cardioprotective strategies.

As evidence of his commitment to advancing knowledge in the field of perioperative echocardiography through education and research, he was elected Fellow of the American Society of Echocardiography status in 2006, and a member of the Association of University Anesthesiologists in 2008.

Grants

  1. Genetics of Myocardial Adverse Outcomes and Graft Failure After CABG (Gene-Magic)
    NIH R01 HL075273-05
    Grant Amount:  $2,136,880.00
    Grant Period:  7/1/2004 - 6/30/2009
    Role:  Principal Investigator (25% effort)
  2. Cross-species Analysis of Myocardial Susceptibility to Perioperative Stress
    NIH R01 HL092971-01
    Grant Amount:  $1,248,706.00
    Grant Period:  9/1/2007 - 8/31/2011
    Role:  Principal Investigator (25% effort)
  3. DUHS Clinical Laboratories Innovation Committee for Translational Laboratory Research Funding: “Predicting Patients at Risk for Perioperative Adverse Events.” Principal Investigator. Grant Period: 2006 – 2008.
  4. American Heart Association # 0120492U: “The Role of Beta2-Adrenergic Polymorphisms in Cardiac Surgery Outcomes.” Principal Investigator. Grant Period: 7/1/2001 - 6/30/2003.
  5. FAER Medical Student Anesthesia Research Fellowship Award, mentor - (Ashley Hawrylyshyn, University of Toronto Medical School).  “Animal surgery that incorporates perioperative genomics studies.” 2006.

Peer-Reviewed Manuscripts

  1. De Lange F, Yoshitani K, Podgoreanu MV, Grocott HP, Mackensen GB. A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper. Journal of Cardiothoracic Surgery 2008 in press.
  2. Phillips-Bute B, Mathew JP, Blumenthal JA, Morris RW, Podgoreanu MV, Smith M, Stafford-Smith M, Grocott HP, Schwinn DA, Newman MF. The relationship of genetic variability and depressive symptoms to adverse events following coronary artery bypass graft surgery. Psychosomatic Medicine 2008 in press.
  3. Akhtar S, Podgoreanu M, Harrison BA, Brull SJ.  Effect of lidocaine on endothelin-1 mediated airway smooth muscle contraction in rat trachea.  Acta Anaesth Scand 2008 in press.
  4. S Martinelli, J Mitchell, R McCann, M Podgoreanu, J Mathew, M Swaminathan. Intraoperative TEE diagnosis of residual tumor fragment after surgical removal of renal cell carcinoma. Anesth Analg 2008;106(6):1633-5.
  5. Schwinn DA, Podgoreanu M. Pharmacogenomics and end-organ susceptibility to injury in the perioperative period. Best Pract Res Clin Anaesthesiol 2008 March;22(1):23-27.
  6. Nicoara A, Mackensen GB, Podgoreanu MV, Milano CA, Mathew JP,.  Malpositioned left ventricular assist device cannula:  Diagnosis and management with transesophageal echocardiography guidance.  Anesth Analg 2007; 105:1574-1576.
  7. Swaminathan M, Morris RW, De Meyts DD, Podgoreanu MV, Jollis JG, Grocott HP, Milano CA, Newman MF, Mathew JP.  Deterioration of regional wall motion immediately following coronary artery bypass surgery is associated with long-term major adverse cardiac events.  Anesthesiology 2007; 107(5):739-45.
  8. Mathew JP, Mackensen GB, Phillips-Bute B, Stafford-Smith M, Podgoreanu MV, Grocott HP, Hill SA, Smith PK, Reves JG, Newman MF, for the Neurologic Outcome Research Group (NORG) of the Duke Heart Center.  Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderly.  Anesthesiology October 2007; 107(4):577-584
  9. Swaminathan M, Grocott HP, Mackensen GB, Podgoreanu MV, Glower DD, Mathew JP.  The ‘sandblasting’ effect of aortic cannula on arch atheroma during cardiopulmonary bypass.  Anesth Analg June 2007; 104(6):1350-1.
  10. Mathew JP, Podgoreanu MV (co-first author), Grocott HP, White WD, Morris RW, Stafford-Smith M, Mackensen GB, Rinder CS, Blumenthal JA, Schwinn DA, Newman MF.  Genetic variants in P-selection and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery.  J Am Coll Cardiol May 2007;49(19):1934-42.
  11. Swaminathan M, Mackensen GB, Podgoreanu MV, McCann RL, Mathew JP, Hughes GC.  Spontaneous echocardiographic contrast indicating successful endoleak management.  Anesth Analg May 2007;104(5):1037-1039.
  12. Podgoreanu MV, White WD, Morris RW, Mathew JP, Stafford-Smith M, Welsby IJ, Grocott HP, Milano CA, Newman MF, Schwinn DA.  Inflammatory gene polymorphisms and risk of postoperative myocardial infarction following cardiac surgery.  Circulation July 2006;114( 1 Suppl):I275-281.
  13. Izrailtyan I, Clark J, Swaminathan M, Podgoreanu MV, Mackensen B, Davis RD, Mathew JP.  Case report:  Optimizing intraoperative detection of pulmonary embolism using contrast-enhanced echocardiography.  Canadian Journal of Anesthesia July 2006;53(7):711-715.
  14. Podgoreanu MV, Mathew JP. Prophylaxis against postoperative atrial fibrillation:current progress and future directions.  JAMA December 2005;294(24):3140-2.
  15. Podgoreanu MV, Schwinn DA.  New paradigms in cardiovascular medicine. emerging technologies and practices: perioperative genomics.  J Am Coll Cardiol December 2005;46(11):1965-77.
  16. Moretti EW, Morris RW, Podgoreanu M, Schwinn DA, Newman MF, Bennett E, Moulin VG, Mba UU, Laskowitz DT.  APOE polymorphism is associated with risk of severe sepsis in surgical patients.  Crit Care Med November 2005;33(11):2521-6.
  17. Grocott HP, White WD, Morris RW, Podgoreanu M, Mathew JP, Nielsen DM, Schwinn DA, Newman MF. Genetic polymorphisms and the risk of stroke after cardiac surgery.  Stroke September 2005;36(9):1854-8.
  18. Schwinn DA, Podgoreanu M.  The new age of medical genomics.  Br J Anaesth August 2005;95(2):119-21.
  19. Podgoreanu MV, Michelotti GA, Sato Y, Smith MP, Lin S, Grocott H, Mathew JP, Schwinn DA.  Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of pro-inflammatory genes.  J Thorac Cardiovasc Surg August 2005;130(2):330-9.
  20. Mathew JP, Grocott HP, McCurdy II JR, Ti LK, Davis RD, Laskowitz DT, Podgoreanu MV, Swaminathan M, Lynch J, Stafford-Smith M, White WD, Newman MF. Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass.  J Cardiothorac Vasc Anesth June 2005;19(3):294-9. 
  21. Welsby IJ, Podgoreanu MV (co-first author), Phillips-Bute B, White WD, Nielsen DM, Mathew JP, Booth JV, Smith PK, Newman MF, Schwinn DA, Stafford-Smith M.  Genetic variants improve prediction of bleeding after elective aortocoronary surgery.  J Thromb Haemos. June 2005;3(6):1206-12.
  22. Stafford-Smith M, Podgoreanu M (co-first author), Swaminathan M, Phillips-Bute B, Mathew JP, Hauser EH, Winn MP, Milano C, Nielsen DM, Smith MP, Morris R, Newman MF, Schwinn DA.  Association of genetic polymorphisms predict acute renal injury after coronary bypass graft surgery.  Am J Kidney Dis March 2005;45(3):519-30.
  23. McKinlay KH, Schinderle D, Podgoreanu M, Milano CA, Messier RH, El-Moalem, H, Newman MF, Clements F, Mathew JP, and Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.) Investigators of the Duke Heart Center. Predictors of inotrope use during separation from cardiopulmonary bypass. J Cardiothorac Vasc Anesth 2004; 18:404-408.
  24. Podgoreanu MV, Schwinn DA.  Genomics and the circulation.  Br J Anaest  July 2004;93(1):140-8.
  25. Djaiani G, Phillips-Bute B, Podgoreanu M, Messier RH, Mathew JP, Clements F, Newman M.  The association of patent foramen ovale and atrial fibrillation after coronary artery bypass graft surgery.  Anesth Analg March 2004;98(3):585-9.
  26. Phillips-Bute B, Mathew JP, Blumenthal JA, Welsh-Bohmer K, White WD, ,Mark D, Landolfo K, Newman MF, Neurologic Outcome Research Group (NORG) and Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.) Investigators of the Duke Heart Center. Female gender is associated with impaired quality of life and cognitive function one year following CABG surgery. Psychosomatic Medicine 2003; 65:952-962.
  27. Mathew JP, Grocott HP, Phillips-Bute B, Stafford-Smith M, Laskowitz DT, Rossignol D, Blumenthal JA, Newman MF, Neurologic Outcome Research Group (NORG) and Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.) Investigators of the Duke Heart Center. Lower Endotoxin Immunity Predicts Increased Cognitive Dysfunction In Elderly Patients After Cardiac Surgery Stroke 2003; 34:508-513
  28. Booth JV, Phillips-Bute B, McCants CB, Podgoreanu MV, Smith PK, Mathew JP, Newman MF.  Low serum magnesium level predicts major adverse cardiac events after coronary artery bypass graft surgery.  Am Heart J June 2003;145(6):1108-13.
  29. Podgoreanu M, Djaiani G, Phillips-Bute B, Davis E, Mathew J.  Quantitative echocardiographic assessment of regional wall motion and left ventricular asynergy with color kinesis in cardiac surgery patients.  Anesth Analg May 2003;96(5):1294-300.
  30. Podgoreanu M, Stout R, ElMoalem H, Silverman D.  Synchronous rhythmical vasomotion in human cutaneous microvasculature during nonpulsatile cardiopulmonary bypass.  Anesthesiology 2002;97(5):1110-7.
  31. Djaiani G, McCreath B, Ti L, Mackensen B, Podgoreanu M, Mathew J.  Mitral flow propagation velocity identifies patients with abnormal diastolic function during coronary artery bypass graft surgery.  Anesth Analg 2002;95:524-30.

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