Division of Cardiothoracic Anesthesia

F. Willem Lombard, MB, ChB, FANZCA

Dr. Willem Lombard received his medical degree from the University of Stellenbosch in South Africa, and completed his residency in Anesthesiology, as well as a fellowship in Liver Transplant Anesthesia, at Auckland Hospital in New Zealand. In 2002, he completed further fellowship training in Cardiothoracic Anesthesia and Critical Care Medicine at Duke University Medical Center. Dr. Lombard was previously a member of the Division of Neurosurgical Anesthesiology but now serves in the Cardiothoracic Anesthesiology and Basic Science Divisions.

Dr. Lombard’s primary research interests are in the prevention of peri-operative cerebrovascular complications. To date his work has focused predominantly on the molecular aspects of vascular and neuronal injury following subarachnoid hemorrhage (SAH). He developed vivo models of SAH with long-term functional outcomes, which he employs in mechanistic and translational studies.  He is currently exploring the role of microvascular dysfunction due to oxidative stress and altered nitric oxide dependent processes in the development of cognitive failure following SAH, as well as in the peri-operative setting.

Grants

1. BioMarin Pharmaceutical Inc: “Tetrahydrobiopterin in Subarachnoid Hemorrhage.” Principal Investigator. Grant Period: 9/2008-9/2009.
2. Nitrox, LCC: “Use of a Nitric Oxide Donor to Reduce Subarachnoid Hemorrhage-Induced Vasospasm.” Principal Investigator. Grant Period: 9/2004-3/2005.
3. FAER Research Starter Grant: The Role of Platelet Derived Growth Factor in the Pathogenesis of Cerebral Vasospasm following Subarachnoid Hemorrhage. Principal Investigator. Grant Period: 06/2004-06/2006.

Peer-Reviewed Manuscripts

1. Takata K, Sheng H, Laskowitz D, Borel CO, Warner DS, Lombard FW. Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: New perspectives. Exp Neurol 2008; 213(2):336-344.
2. Mesis RG, Wang H, Lombard FW, Yates R, Vitek MP, Borel CO, Warner DS, Laskowitz DT. Dissociation between histological vasospasm and functional improvement in a murine model of subarachnoid hemorrhage. Neurosurg Focus 2006; 21: E4.
3. Miller CA, Lombard FW, Wu C, Hubbard C, Silbajoris L, Borel CO, Niklason LE. Role of Vascular Mitogens in Subarachnoid Hemorrhage Associated Cerebral Vasculopathy. Neurocrit Care 2006; 5 (3):1-7.
4. Lombard FW, Welsby IJ, Alexander MJ, Borel CO. Thromboelastography detects inadequate response to abciximab therapy during stent-assisted cerebral aneurysm coil embolization complicated by stroke. Neurocrit Care 2006;4(1):32-4.
5. Gonzales J, Lombard FW, Borel CO. Pressure support mode improves ventilation in “Asleep-Awake-Asleep” craniotomy. J Neurosurg Anesthesiol 2006 Jan; 18(1) :88.
6. Lombard FW, Welsby IJ, Booth JV.  Systemic air embolism during off-pump coronary artery bypass surgery. J Cardiothorac Vasc Anesth 2003 Jun;17(3):403-4.

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